Grant: $119,967 - National Institutes of Health - Sep. 30, 2009
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Award Description: YidC is an evolutionarily conserved protein involved in the membrane biogenesis of respiratory proteins, energy transduction proteins, ATPases, signaling molecules and transporters. YidC can function as a membrane insertase either independently or cooperatively with the SecYEG translocase. For proteins inserted by the Sec-dependent pathway, YidC may also serve as an integrase or chaperone where it assists in the lateral integration and folding of membrane proteins. This R01 supplement grant will determine the function of YidC in the folding of membrane proteins and in promoting the integration of membrane proteins into the membrane bilayer. It will also define the YidC-YidC interfacial region that is believed to form the dimeric insertion pore that facilitates membrane protein insertion. These studies will impact the field of membrane protein insertion in bacteria and will advance the knowledge of similar pathways in eukaryotic cells.
Project Description: The project, as defined in the Award Description field, is being initiated.
Jobs Summary: Not applicable (Total jobs reported: 0)
Project Status: Not Started
This award's data was last updated on Sep. 30, 2009. Help expand these official descriptions using the wiki below.