Grant: $544,743 - National Institutes of Health - Jul. 21, 2009
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Award Description: The purpose of this R21/R33 investigation is to satisfy the critical unmet norepinephrine transporter (NET) tracer need. The investigation will afford candidate NET Positron emission Tomography (PET) imaging agents with unique in vitro structure-activity relationships and efficacious in vivo pharmacokinetic imaging profiles suitable for quantifying NET density in primate brain. We will staisy the milestones on the R21 portion of the investigation by medicinal chemistry, radiopharmaceutical and PET imaging screenting studies, which will identify at least two structurally novel, potent and selective NET tracers possessing appropriate regional cerebral activity distributions correlated to known NET density profiles and cerebral tissue pharmacokinetic rproperties suitable for determining NET densities by kinetic analyses. The R33 development segment of the investigation will delineate one (or more) efficacious cerebral NET PET imaging radioligand as a candidate tracer(s) by in depth quantitative PET imaging experiments, followed by tracer toxicological-safety determinations and the FDA approval of an exploratory investigation new drug (elND) application for future human clinical evaluations. The investigation will further evaluate several contemporary hypotheses encompassing radidoligand discovery, tracer development and quantitative PET imaging of primate brain.
Project Description: (See Award Description) Postdocs hired, technician student hired and plan systhetic chemistry and pharmacological measures 7% complete. One analog examined completely 100% complete. Discussed possigilities for initial radiolabling experiments, details of the subcontract and calendar planning for start of the Yale experiments 3% completed.
Jobs Summary: 2 full-time Post Doctoral positions, 1 half-time Associate Professor (Total jobs reported: 3)
Project Status: Less Than 50% Completed
This award's data was last updated on Jul. 21, 2009. Help expand these official descriptions using the wiki below.