Grant: $1,771,013 - National Institutes of Health - Sep. 28, 2009
No votes have been cast for this award yet
Award Description: The focus of this competing continuation proposal is the localization and characterization of susceptibility genes for Tourette's Disorder (TD) and related conditions. The investigators are members of a longstanding international collaboration, the Tourette Syndrome Association International Consortium on Genetics (TSAICG). Previous studies completed by members of this group suggest that the mode of transmission of TD and related disorders is consistent with the existence of genes that have a significant impact on the manifestation of TD. During the current award we conducted a genomewide linkage analysis of our samples of affected sibpair and multigenerational families. The results pointed strongly to a TD locus on Chromosome 2p [-log(p) = 4.00] and also provided evidence for several additional TD localizations, with -log(p) scores ranging from 2.0 to 3.5. We are proposing three genetic mapping studies using high-throughput SNP genotyping: Project 1 will follow up our linkage findings with fine-mapping genotyping, focusing particularly on 2p; Project 2 will search for additional TD loci through a whole genome association study on 800 trios ascertained from isolated populations; Project 3 will follow up the results of Projects 1 and 2, with a very dense set of SNPs to be genotyped in a sample (n=7200) with substantial power to detect association. The results of Project 3 will lead to genetic investigation of a small number of positional candidate genes. Functional studies of the most promising candidate genes identified through the above studies will be undertaken. Phenotypic data for new subjects sampled during the first two years of this proposal will be obtained by direct semi-structured interview of affected children and both parents. Additional analyses are proposed to define more accurately the inherited components of the TD phenotype.
Project Description: No Activity
Jobs Summary: Research Assistants are responsible for handling the recrutment process for the project while assisting with data entry,tracking of DNA samples and assisting with the collection of data. Project Coordinator - Coordinate all aspects of the project. Post-doctoral Fellow will conduct interviews for the asseements to be used in the study. Database Assistant-Enter the data. We will create new jobs and preserve existing jobs, primarily in the four metropolitan areas in which the investigative teams are located (Boston, Chicago, Los Angeles, and San Francisco), but also in multiple sites across the country where we will ascertain and assess new TS samples. (Total jobs reported: 10)
Project Status: Not Started
This award's data was last updated on Sep. 28, 2009. Help expand these official descriptions using the wiki below.