Grant: $72,000 - National Institutes of Health - Sep. 21, 2009
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Award Description: The goal of the parent grant was to create a database/webtool that could be used to identify minimotifs that were potentially new HIV drug targets. Minimotifs are short peptide sequences that have a known molecular function in at least one protein. The funded aims in the parent grant were 1) To identify functional short sequence motifs conserved among different HIV isolates and 2) To plot predicted motifs onto the surface of HIV proteins. Through our initial efforts on this grant and interactions with other HIV investigators, we have come to recognize that there is just as much value in producing a tool that integrates existing HIV data as there is for predicting minimotifs as potential drug targets. This supplement will broaden the scope of this web tool be building a HIV tool that integrates drug binding data from the National Institute of Standards and Technology (NIST) HIV structure database, sequence data from Los Alamos National Laboratory (LANL) HIVdb, drug resistance data from the Stanford HIV database, protein-protein interaction data from the HIV Protein-Protein Interaction database, with minimotif predictions and verified motif interaction from the MnM database. This project would create a new job for a postdoctoral fellow. As we begin to develop this project into a new application, we would hope to sustain funding of the newly created position into the future. To accomplish these goals we have designed the following new aims that a newly hired Fellow should be able to complete in the 8 month scope of this project. The new specific aims are: 1)To add a new structure viewer that maps HIV drugs and drug resistant mutations for comparison. 2) To implement new selection filters for mapping protein surface of HIV proteins. These aims will make this site of particular interest to pharmaceutical companies and those involved in identifying new HIV drug leads.
Project Description: As defined in the Award Description field.
Jobs Summary: None (Total jobs reported: 0)
Project Status: Not Started
This award's data was last updated on Sep. 21, 2009. Help expand these official descriptions using the wiki below.