Grant: $99,675 - National Institutes of Health - Sep. 22, 2009
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Award Description: Periodontal disease initiation and progression occurs as a consequence of the host immune inflammatory response to oral pathogens. The purpose of this award is to 1)determine the role of over-expressed MKP-1 on IL-6 and TNFalpha mRNA in vitro, 2)determine the contribution of MKP-1 in ontogeny of inflammatory cytokine production and LPS-induced osteoclastogenesis in primary bone marrow macrophages and 3)determine the impact of MKP-1 in inflammatory bone destruction in vivo using MKP-/- mice. These studies will establish the role of LPS-induced cytokine expression and negative regulation in inflammatory bone loss through selective attenuation of p38 MAPK-induced signaling in periodontal bone destruction.
Project Description: As defined in the Award Description field
Infrastructure Description: N/A
Jobs Summary: None. (Total jobs reported: 0)
Project Status: Not Started
This award's data was last updated on Sep. 22, 2009. Help expand these official descriptions using the wiki below.