GEORGETOWN UNIVERSITY (THE)
Grant: $10,131 - National Institutes of Health - Jul. 14, 2009
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Award Description: This supplement will support an summer intern who will carry out experiments related to Aim #3: Test the hypothesis that RAG1 ubiquitin ligase activity/ubiquitylation promotes V(D)J recombination in cells and that ubiquitylation modulates RAG1?s other biochemical activities in vitro. RAG1 proteins with mutations in the RING finger or positions of RAG1 ubiquitylation will be tested for their ability to support V(D)J recombination and ubiquitylation of RAG1. Expression and turnover of these mutants will also be measured. These experiments will be carried out in RAG1-/- pro-B cells. The addition of a summer intern will be critical to completion of the aim prior to the conclusion of the funding period, because two of the three full-time researchers supported by this project will be on maternity leave for the bulk of the summer. In addition, the summer intern can not be hired without the supplement, because all current funding is committed to meet the salaries of current staff.
Project Description: The undergraduate funded by this award has completed her sub-cloning project. She is likely to return next summer if we can get a no-cost extension of the award.
Jobs Summary: Student Researcher: I job was created for an undergraduate student to work in the laboratory for the summer. To report the economic impact of the ARRA funds on the University (i.e., ARRA supported FTE?s), we calculate the number of FTE?s created or retained for each project in the following manner: (1) A baseline FTE for each employee is calculated based upon employee?s status as full or part time adjusted for the ratio of the periods for which the employee was paid over to total periods being reported; and (2) the calculated FTE is than adjusted for the portion of the employee's salary which is being supported by the ARRA project during the period. The portion is based upon planned effort adjusted for variances. (Total jobs reported: 1)
Project Status: More than 50% Completed
This award's data was last updated on Jul. 14, 2009. Help expand these official descriptions using the wiki below.
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