CHILDREN'S HOSPITAL & RESEARCH CENTER AT OAKLAND
Grant: $1,422,674 - National Institutes of Health - Sep. 11, 2009
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Award Description: This award is intended to support the following aims: (1) accelerate the human leucocyte antigen (HLA) genotyping efforts in our case/control study of the role of HLA and killer-cell immunoglobulin-like receptor (KIR) polymorphism in Crohn's Disease (CD) and Rheumatoid Arthritis (RA) through increases in the effort of personnel already on the project, and the hiring of new personnel for the project, and through the manufacture of new HLA genotyping reagents; (2) validate our next-generation high-throughput HLA and KIR sequence-based typing (SBT) genotyping assays on the Roche 454 Genome Sequencer (GS) FLX instrument through its application to our study of HLA and KIR in CD and RA; and (3) develop our resources for the management and analysis of highly-polymorphic HLA and KIR genotype data generated in our study through collaboration and partnership with the CHRCO Center for Applied Genomics and the NIAID Bioinformatics Integration Support Contract (BISC), making these data available to the scientific community through DAIT’s Immunology and Data Analysis Portal (ImmPort).
Project Description: We have purchased new equipment (e.g., new computers and external storage media), laboratories supplies (e.g., glassware, micropipette tips), and reagents (e.g., nylon transfer membrane) in pursuit of project aims 1, 2, and 3. We have increased the effort of five staff members, and have hired a new staff member (who would otherwise be unemployed due to a lack of funding), in pursuit of aims 1, 2, and 3. We have begun the manufacture of new reagents as outlined in aim 1, have begun redevelopment of primers for KIR and HLA sequencing as outlined in aim 2, and have begun the development of data management resources as outlined in aim 3.
Jobs Summary: Individuals were identified and will be hired in October 2009.Some work has began on the project. (Total jobs reported: 0)
Project Status: Less Than 50% Completed
This award's data was last updated on Sep. 11, 2009. Help expand these official descriptions using the wiki below.
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