Grant: $247,640 - National Institutes of Health - Sep. 3, 2009
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Award Description: This project is an administrative supplement to a parent R21 grant. The parent grant was designed to solidify an interdisciplinary team of basic and clinical researchers in the Center for Environmental Health Sciences at Mississippi State University for research into the environmental factors contributing to the higher mortality of cardiovascular disease (CVD) in the Deep South and among African Americans. This health disparity in CVD is logically related to risk factors more prevalent in the South (which has a higher proportion of African Americans, 36%, than other regions in the country.) The South is rural and highly agricultural, so the Southern populations would be expected to be routinely exposed to higher levels of pesticides than populations in other regions. We hypothesized the following: The effects of pesticide exposure contribute to the development of CVD and are more pronounced in the African American population. The parent grant has studied paraoxonase (PON1), both activity levels and functional genotypes that influence its ability to protect against CVD. We have found substantial racial differences in the proportions of functional genotypes which is likely to be an influence in the health disparities displayed by African Americans. We are conducting a pilot study to investigate the association of various risk factors (i.e., PON1, demographic and clinical information) with CVD in 200 subjects, 40 each African American males and females and 60 each Caucasian males and females. This ARRA administrative supplement will use the blood samples from this cohort of 200 subjects to investigate two additional CVD risk factors: the presence of type 2 diabetes/prediabetes/metabolic syndrome and the presence of 14 legacy organochlorine pesticides. Diabetes/prediabetes will be assessed from fasting blood glucose levels and the organochlorine pesticides will be assessed by gas chromatography/mass spectrometry. The value of the project for risk prediction will be increased by obtaining more useful information from the already collected blood samples, thus accelerating the tempo of the scientific research. The supplement will also allow the creation/retention of jobs for 4 individuals for whom support is not available.
Project Description: As defined in the award description field.
Jobs Summary: No jobs to report yet. (Total jobs reported: 0)
Project Status: Less Than 50% Completed
This award's data was last updated on Sep. 3, 2009. Help expand these official descriptions using the wiki below.