SAN DIEGO STATE UNIVERSITY FOUNDATION
Grant: $33,638 - National Institutes of Health - Jun. 17, 2009
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Award Description: The Fetal Alcohol Effects and Choline Intervention project examines the potential of choline, an essential nutrient, to reduce the severity of neuropathology and behavioral alterations associated with developmental alcohol exposure. Using an animal model of third trimester alcohol exposure, the program examines the temporal windows of choline's effectiveness on behavioral development and found that choline can be effective in reducing alcohol-related cognitive deficits, even when adminstered after alcohol exposure. The project further examines whether perinatal choline supplementation leads to long-lasting changes in hippocampal and cortical cholinergic functioning in alcohol-exposed subjects, allowing the project to correlate behavioral changes with neurochemical substrates.
Project Description: The Fetal Alcohol Effects and Choline Intervention project examines the potential of choline, an essential nutrient, to reduce the severity of neuropathology and behavioral alterations associated with developmental alcohol exposure. Using an animal model of third trimester alcohol exposure, the program examines the temporal windows of choline's effectiveness on behavioral development and found that choline can be effective in reducing alcohol-related cognitive deficits, even when adminstered after alcohol exposure. The project further examines whether perinatal choline supplementation leads to long-lasting changes in hippocampal and cortical cholinergic functioning in alcohol-exposed subjects, allowing the project to correlate behavioral changes with neurochemical substrates. Three undergraduate students have been working in the laboratory over the summer months, gaining knowledge and research experience in the field of fetal alcohol spectrum disorders. One student attended this year's annual meetings of the Research Society on Alcoholism and the Fetal Alcohol Spectrum Disorders Study Group. By attending this meeting, the student was able to broaden his understanding of alcohol research.
Jobs Summary: Created 2.44 Student Research Assistant jobs. (Total jobs reported: 2)
Project Status: More than 50% Completed
This award's data was last updated on Jun. 17, 2009. Help expand these official descriptions using the wiki below.
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