Grant: $53,783 - National Institutes of Health - Sep. 30, 2009
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Award Description: The administrative supplement will allow an increase in the recruitment of a general population cohort from 400 participants to 600 participant over the next 2 years. This will translate into a relevant improvement in statistical power for comparing renal function assessment by different methods. Two community cohorts already extensively characterized by Mayo Clinic investigators for cardiovascular disease risk factors are being studied. The Genetic Epidemiology Network of Arteriopathy (GENOA) cohort includes 800 black (Jackson, MS) and 800 white (Rochester, MN) hypertensive sibships that are currently undergoing glomerular filtration rate (GFR) measurements and this is funded by the mentor's grant (R01 DK073537) and has recently started the 4th of 5 years of funding. For a cohort more representative of the general population in Rochester, MN, the Epidemiology of Coronary Artery Calcification (ECAC) cohort (n=400) are also being studied under the parent grant (K23 DK 78229) this is currently in the 2nd of 5 years of funding. This administrative supplement will increase the recruitment in the ECAC cohort from 400 and 600 persons. Specific Aim #1. Compare GFR and the prevalence of reduced GFR (e.g., <60mL/min/1.73 m2) between gold standard iothalamate clearance and convenient methods [cystatin C, serum creatinine (SCr)], estimated GFR [MDRD or other equations] and creatinine clearance) in community-based samples (ECAC and GENOA) in order to characterize bias with methods commonly used to estimate GFR. Specific Aim #2. Compare coronary artery clacification and cardiovascular risk factors (e.g., hypertension, diabetes mellitus, age, sex, race, albuminuria) with GFR by iothalamate clearance and with GFR by convenient methods (cystatin C, serum creatinine, estimated GFR, and creatinine clearance) in community-based samples (ECAC and GENOA) in order to determine whether convenient methods lead to biased associations with chronic kidney disease in the community setting.
Project Description: As defined in the award description field.
Jobs Summary: This project has not started (Total jobs reported: 0)
Project Status: Not Started
This award's data was last updated on Sep. 30, 2009. Help expand these official descriptions using the wiki below.