Grant: $89,289 - National Institutes of Health - Sep. 28, 2009
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Award Description: Project I The goal of Project I is to examine candidate genes based on the convergence of evidence as a PD risk factor from different studies (association, linkage and expression), and to enhance these efforts by including analysis of complex genetic and environmental interactions in our large family sample. We have made excellent progress on our specific aims, with 16 peer-reviewed papers in the past 5 years. As part of our Program Project, we have recently completed a GWAS of 613 PD cases and 642 controls from our dataset. Our initial analysis showed some expected candidate genes among our most significant results, e.g., SNCA, MAPT and PARK2. However, these are buried in a sea of significant results. While the information content of a GWAS is extraordinarily high, the initial false positive rate is also high. Investigating each of the thousands of SNPs that will reach nominal significance is arduous and inefficient. The primary solution to this problem is validation in additional datasets. Through this supplement, we plan to validate our top replicated genes in the NINDS PD sample. Following the parent grant, we will conduct association analysis, gene-gene and gene-environment interaction analyses in this independent dataset
Project Description: Because the notice of award was just received on 9/30/09, no progress has been made.
Infrastructure Description: N/A
Jobs Summary: Because the notice of award was just received on 9/30/09, no jobs have been created. (Total jobs reported: 0)
Project Status: Less Than 50% Completed
This award's data was last updated on Sep. 28, 2009. Help expand these official descriptions using the wiki below.