Grant: $393,646 - National Institutes of Health - Sep. 17, 2009
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Award Description: ARRA funds will be used to launch two pilot projects that involve nearly all COBRE faculty to foster collaborations. We specifically plan to obtain critical new information regarding the interaction of microorganisms that we study with two early innate human response pathways, the RNA-sensing RIG-I helicase system to generate IFN?/?, and the NLRP-activated inflammasome. This combines our microbiologists' expertise in RNA viruses and parasites with the immunologists' expertise in immune signal pathways. As such it will involve the majority of our COBRE faculty. It will also combine the microbiological expertise of the COBRE faculty (especially with RNA viruses and parasites) with the signaling expertise of Dr. Ralph Budd, COBRE PI, in caspase-8 and c-FLIP regulation of cell signaling, as well as Dr. Cory Teuscher in the interaction of anthrax with the inflammasome. The clear intent is to use the results gained over the next two years to foster the development of collaborative R01 and Program Project Grants. Consistent with the spirit of the ARRA program, the proposed studies can be performed within two years and will result in the hiring of one new Research Associate (Dr. Iwona Buskiewicz) to perform the RNA and one new technician who will perform the needed high throughput screening assays.
Project Description: See Award Description above
Infrastructure Description: n/a
Jobs Summary: 00 (Total jobs reported: 0)
Project Status: Not Started
This award's data was last updated on Sep. 17, 2009. Help expand these official descriptions using the wiki below.