Grant: $712,495 - National Institutes of Health - Sep. 7, 2009
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Award Description: The overall goal of the Hemodialysis Fistula Maturation Consortium (HFMC), a U01-funded partnership of NIDDK with six Clinical Centers (CCs) & a Data Coordinating Center (DCC), is to better understand the causes and consequences of arteriovenous fistula (AVF) maturation.Since its Sept. 2008 initiation, the HFMC has designed a prospective cohort study to identify predictors of clinical and physiological AVF maturation outcomes through i) standardized collection of pre-operative & intra-operative clinical and surgical data, and pre-operative uniform, centrally-read ultrasound imaging (US), & ii) post-operative observation of fistula development & utilization including US at week 6, & at the earlier of first cannulation, fistula-salvage surgery, or six months without either. The study will allow identification of predictors of maturation failure vs. success with more extensive & reliable data from a larger & more diverse patient sample than previously available, & is expected to identify an accurate 6-week predictor of maturation for clinical use & as a surrogate outcome in future intervention studies.We are requesting ARRA funding for additional staffing & other needed support to enroll 600 patients within 18 rather than 27 months, & to incorporate into the study the following additional procedures: i) pre-operative vascular function studies (brachial artery flow-mediated dilation, arterial pulse wave velocity, & venous occlusion plethysmography), ii) collection of vein tissue for current histologic studies & future molecular analyses, & iii) US studies of early post-surgical vascular response.The additions to the protocol are within the current HFMC scope; some were specifically encouraged in RFA-DK-07-007 creating the Consortium. Proposed vascular function studies, biosample collection, & early post-op ultrasounds all must be performed shortly after each subject's enrollment; thus, all proposed tasks can be readily accomplished within the 2 year ARRA time-frame (which will encompass the reduced enrollment period even allowing for some slippage in our enrollment projections). Linked to data from the currently-funded HFMC study, the proposed additions will greatly increase our ability to test key hypotheses and create broad and long-lasting scientific opportunities for the HFMC.
Project Description: Notification of this ARRA award was issued on September 7th, for a start date of September 11th 2009 . Since receiving the award, Dr Alpers has begun working on setting up the Histopathology Core facility for the Hemodialysis Fistula Maturation (HFMC) Consortium, and is now drawing salary from the grant for this purpose. Training for the ultrasound technician to be employed with ARRA funds has been scheduled for October 2009. The research coordinator funded on the ARRA grant has begun the process of submitting the consortium protocol for Institutional Review Board approval.
Jobs Summary: PROFESSOR-Requires outstanding, mature scholarship and research as evaluated in terms of national or international recognition, and evidenced by accomplishments in full range of academic responsibilities. (Total jobs reported: 0)
Project Status: Less Than 50% Completed
This award's data was last updated on Sep. 7, 2009. Help expand these official descriptions using the wiki below.