RFCUNY - BROOKLYN COLLEGE
Grant: $39,580 - National Institutes of Health - Sep. 28, 2009
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Award Description: To support small scale research projects conducted by faculty in primarily baccalaureate degree-granting domestic institutions. Awards are for up to $75,000 for direct costs (plus applicable indirect costs) for periods not to exceed 36 months.
Project Description: This awarded administrative supplement aims to accelerate progress of project 2R15 GM065885-02 that is funded until 8/31/2010 by NIGMS under NIH Academic Research Enhancement Award (AREA). The central hypothesis is that cortical events activate signaling pathways that affect microtubule stability. This hypothesis is to be tested by studying the effect of osmotic stabilizers on the microtubule cytoskeleton and elucidating the signaling pathways that affect microtubule stabilization. The Three Specific Aims that were approved by the IRG to achieve this are: Aim 1: To determine the phenotypic effect of osmolytes on the microtubule cytoskeleton Aim 2: To identify gene products that function in the pathway(s) through which hyperosmotic conditions affect microtubule stability and suppress cin8 mutations. Aim 3: To construct a model that shows the cascade of signaling pathways that mediate microtubule stability and signaled by osmotic conditions. More specifically, the funds will be used to purchase a high-end fluorescence microscope that will allow us to study the effect of osmotic pressure on processes affected by dynamic instability of microtubules. It would also serve to determine the effect of mutations in microtubule motor proteins on the cell cycle-dependent localization of Swi6p, the transcription cofactor that forms complexes with the DNA-binding proteins Swi4p and Mbp1p to regulate transcription at the G1/S transition. Results obtained under this project will advance our understanding of how microtubule dynamics is regulated in health and disease.
Project Status: Not Started
This award's data was last updated on Sep. 28, 2009. Help expand these official descriptions using the wiki below.
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