Grant: $71,546 - National Institutes of Health - Sep. 30, 2009
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Award Description: The parent grant, 'Molecular Structure and Function of the Human Kinetochore Outer Plate , funds efforts to determine the structure of the human kinetochore in order to better understand how it functions. The human kinetochore performs several tasks that are essential for proper cell division, which in turn is vital for preventing cancer, birth defects, and problems in childhood development. The major challenge currently faced in the accomplishing accurate structural determination of the kinetochore outer plate is preparing frozen hydrated tissue culture cells thin enough for imaging kinetochores by cryo-electron tomography. Researchers at our institution have recently developed a greatly improved method to thin frozen-hydrated cells using a focused ion beam (FIB). Recovery Act stimulus funds will be used to purchase a cryo-light microscope stage to screen frozen-hydrated specimens prior to FIB milling, and salary for lab personnel to use this equipment. Pre-screening by cryo-light microscopy will significantly improve the efficiency of FIB milling by enabling us to locate optimal areas in mitotic cells for finding kinetochores. Hence, the Recover Act Administrative Supplement will accelerate the tempo and increase the effectiveness of research efforts on the parent grant without changing its scope or goals. The supplement will also advance the goals of the American Recovery and Reinvestment Act by increasing the hours of part time staff, gaining additional needed skills in the lab, and purchasing a piece of American made equipment
Project Description: NOT YET STARTED
Jobs Summary: None to report (Total jobs reported: 0)
Project Status: Not Started
This award's data was last updated on Sep. 30, 2009. Help expand these official descriptions using the wiki below.