Grant: $325,773 - National Institutes of Health - Sep. 22, 2009
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Award Description: The experiments proposed in this study were designed to investigate the role played by the phosphatidylinositol 3-kinase (PI3K) signaling pathways mediating leptin action on reproduction. These studies were proposed to better understand the role of the adipocyte-derived hormone leptin in reproductive control. Our main objective is to add knowledge on how the brain integrates nutritional cues to regulate many parameters of the female reproductive physiology. In humans, states of negative energy balance as in anorexia, cachexia, and excessive exercise can all decrease gonadotropins secretion resulting in abnormal cyclicity and infertility. Obesity and diabetes can also negatively affect fertility. Thus, it is hoped that our studies may open new fronts for the understanding and for further treatment of reproductive deficits caused by metabolic dysfunctions.
Project Description: As defined in the Award Description field
Jobs Summary: Positions have not yet been filled (Total jobs reported: 0)
Project Status: Not Started
This award's data was last updated on Sep. 22, 2009. Help expand these official descriptions using the wiki below.