THE GEORGE WASHINGTON UNIVERSITY
Grant: $324,738 - National Institutes of Health - Jul. 16, 2009
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Award Description: Specific Aims are to determine: (1) The mechanistic basis of Pak1 stimulation by DSB damage and role of Pak1 in DSB signaling in breast cancer cells; (2) The molecular basis and significance of MORC2’s contribution in DNA damage response. Specific Aims are to determine: (1) The mechanistic basis of Pak1 stimulation by DSB damage and role of Pak1 in DSB signaling in breast cancer cells; (2) The molecular basis and significance of MORC2’s contribution in DNA damage response Year 1 0-3 months: Active recruitment of staff; establish the mechanistic basis of Pak1 stimulation by DSB damage in cancer cells, including breast cancer cells. 4-6 months: Active recruitment of staff; establish the role of Pak1 in DSB signaling in cancer cells. 7-9 months: Define the molecular basis and significance of MORC2’s contribution in DNA damage response. 0-12 months: Complete the above studies and publish one or more peer-reviewed research publications directly resulting from these studies. Note: The progress may or may not be reported in the precise order established above but will be completed in Year 1. Year 2 0-3 months: Establish the role of Pak1 or MOCR2 interacting protein in DNA damage response. 4-6 months: Establish the role of Pak1 or MORC2 in genome wide recruitment in health or DNA-damaged cancer cells. 7-9 months: Define the role of Pak1 and/or MORC2 targeted approaches in radio-sensitivity of cancer cells. 10-12 months: Complete the above studies and publish one or more peer-reviewed research publications directly resulting from these studies. Note: The progress may or may not be reported in the precise order established above but will be completed in Year 2.
Project Description: Award was received at the end of the reporting period and work has just started.
Jobs Summary: Research Assistants assist in the study of the molecular basis and significance of MORC2's contribution in the DNA damage response (Aim 2). (Total jobs reported: 1)
Project Status: Less Than 50% Completed
This award's data was last updated on Jul. 16, 2009. Help expand these official descriptions using the wiki below.
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