Grant: $225,000 - Department of Health and Human Services - Jun. 1, 2009
33% voted satisfied - 67% voted not satisfied - 3 vote(s) cast
Award Description: Novel class of peptidomimetics, and cyclic peptidomimetics have become appealing targets for the design of therapeutic agents with increased pharmacological activities. Therapeutic potential and demand of opioid analgesics have initiated numerous amounts of scientific efforts, which have resulted in development of a number of new opioid analgesics and significant expansion of knowledge on the opioid pharmacology. Structurally diverse ligands are needed to aid in the study of the mechanisms of analgesic efficacy, addiction and tolerance, and may lead to effective new forms of analgesics or alternative treatments for drug abuse. Therefore, we propose an innovative design for the synthesis of new oligoheterocyclic peptidomimetics. All the proposed compounds will be screened internally in different assays for opioid activity in mu, delta, and kappa opioid receptors.
Project Description: Synthesis of enkephalin peptidomimetics: We synthesized 12 Leu-enkephalin analogs, where we incorporated a variety of heterocyclic compounds to the modified peptide backbone such as: cyclic-urea, diketopiperazines, piperazines and, cyclic guanidine. All the compounds will be purified and screened for opioid activity.
Jobs Summary: Prime Recipient Retained Principal Investigator and Research Technician (Total jobs reported: 1)
Project Status: Less Than 50% Completed
This award's data was last updated on Jun. 1, 2009. Help expand these official descriptions using the wiki below.