Grant: $378,570 - National Institutes of Health - Sep. 25, 2009
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Award Description: Although a wide range of environmental stimuli have been proposed to play a role in the pathogenesis of autism spectrum disorders, many of these stimuli have in common the ability to alter immune function. Since cytokines mediate the immune response, are present in the developing brain, and regulate cortical plasticity and connectivity, factors that alter cytokines during development may lead to changes in synaptic connectivity that contribute to ASD. The goals of this proposal are to define the full complement of cytokines that are changed in specific regions of the CNS of offspring at various postnatal ages following MIA and to determine the effects of those cytokines on connectivity and function in several cortical regions at the relevant postnatal ages.
Project Description: This project was just awarded. The subcontract will be finalized next week. We started the first experiment in Aim 1 last week with success.
Jobs Summary: One job was maintained during the reporting period, that of our technician. We plan to hire a new postdoctoral fellow to complete this work; she will start her new position in January 2010. (Total jobs reported: 0)
Project Status: Not Started
This award's data was last updated on Sep. 25, 2009. Help expand these official descriptions using the wiki below.