Grant: $474,750 - National Institutes of Health - May. 21, 2009
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Award Description: The overall goal of the proposal is to determine the mechanisms responsible for the super agonist activity of cytokine/anti-cytokine mAb complexes. The biological activity of many administered cytokines can be greatly boosted by first binding the cytokine to a specific anti·cytokine mAb prior to their injection. While the bound mAb is thought to mediate its enhancing role by extending the short lifespan of the cytokine, other mechanism(s) appears to be involved, as extension of cytokine lifespan by other approaches do not usually lead to the same level of enhancement. We expect to find additional mechanism(s) important in increasing the activity of cytokine/mAb complexes. The information gained from this proposal may lead to design of better therapeutic approaches to boost the immune system for combating cancer and infectious diseases.
Project Description: As defined in Award Description field.
Jobs Summary: The funding provided for this proposal maintained employment of a professor and one research technician. The funding also allowed partial support to retain one research associate. (Total jobs reported: 1)
Project Status: Less Than 50% Completed
This award's data was last updated on May. 21, 2009. Help expand these official descriptions using the wiki below.