The Vanderbilt University
Grant: $977,864 - National Institutes of Health - Sep. 21, 2009
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Award Description: This 2-year Administrative Supplement application is submitted in response to the American Recovery and Reinvestment Act (ARRA) of 2009, NCI-Activities to Promote Research Collaboration (NCI-APRC). The parent grant of this application is the NCI-funded R01 project: Breast Cancer Survival: Lifestyle and Genetic Determinants (study name: Shanghai Breast Cancer Survival Study), a cohort study of 5000 Chinese breast cancer survivors. The primary focus of the parent study is to investigate the effect of genetic variations and lifestyle factors on survival and quality of life. We propose to extend this research by conducting a pooling analysis using the resources collected by the parent study and three other ongoing, NCI-funded cohort studies: the Life After Cancer Epidemiology Study, Pathways: a Study of Breast Cancer Survivorship, and the Nurses’ Health Study. The expanded study will comprehensively evaluate the influence of lifestyle factors and their interactions with cancer treatment on the prognosis of breast cancer by subtypes of cancer, particularly estrogen receptor (ER) and progesterone receptor (PR) negative or triple negative (ER, PR, and HER2 negative) breast cancer, about which there is little existing knowledge. The proposed study, following the overall theme of the parent study and extending its rigorous scientific approach, will bring together the unique, existing resources of four well-established cohort studies of breast cancer survivors, which will greatly enhance the statistical power needed to address novel hypotheses related to modifiable prognostic factors for breast cancer survival. More importantly, the collaboration will create a synergy among investigators with multidisciplinary expertise in the areas of molecular epidemiology, epidemiology, nutrition, cancer treatment, and survivorship who have not previously collaborated, which would greatly accelerate research on topics of significant scientific and public health relevance. The proposed pooling analysis would also set the stage for future collaborations within the newly formed Breast Cancer Consortium for Outcomes and Survival (BC2OS), thus promoting broader collaborations within the breast cancer survivor research community.
Project Description: The parent grant of this application is the NCI-funded R01 project: Breast Cancer Survival: Lifestyle and Genetic Determinants (study name: Shanghai Breast Cancer Survival Study), a cohort study of 5000 Chinese breast cancer survivors. The primary focus of the parent study is to investigate the effect of genetic variations and lifestyle factors on survival and quality of life. We propose to extend this research by conducting a pooling analysis using the resources collected by the parent study and three other ongoing, NCI-funded cohort studies: the Life After Cancer Epidemiology Study, Pathways: a Study of Breast Cancer Survivorship, and the Nurses’ Health Study. The expanded study will comprehensively evaluate the influence of lifestyle factors and their interactions with cancer treatment on the prognosis of breast cancer by subtypes of cancer, particularly estrogen receptor (ER) and progesterone receptor (PR) negative or triple negative (ER, PR, and HER2 negative) breast cancer, about which there is little existing knowledge. The proposed study will bring together the unique, existing resources of four well-established cohort studies of breast cancer survivors, which will greatly enhance the statistical power needed to address novel hypotheses related to modifiable prognostic factors for breast cancer survival. More importantly, the collaboration will create a synergy among investigators with multidisciplinary expertise in the areas of molecular epidemiology, epidemiology, nutrition, cancer treatment, and survivorship who have not previously collaborated, which would greatly accelerate research on topics of significant scientific and public health relevance. The proposed pooling analysis would also set the stage for future collaborations within the newly formed Breast Cancer Consortium for Outcomes and Survival (BC2OS), thus promoting broader collaborations within the breast cancer survivor research community.
Jobs Summary: Not Applicable at this time. (Total jobs reported: 0)
Project Status: Not Started
This award's data was last updated on Sep. 21, 2009. Help expand these official descriptions using the wiki below.
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