UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE
Grant: $450,293 - National Institutes of Health - Sep. 24, 2009
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Award Description: The University of Vermont (UVM) has a long and venerable history of research using rodent models of environmental lung disease developed within a dedicated inhalational exposure facility housed in the College of Engineering at UVM. This facility has been maintained and operated for nearly 30 years by Dr. David Hemenway, a renowned expert in the hardware and procedural aspects of inhalational exposure, but is currently being decommissioned and must be replaced. This is crucial for keeping UVM investigators successful in today’s highly competitive funding climate, and for future hiring of faculty and staff, particularly within the College of Medicine. We therefore face a critical need for a new, state-of-the-art facility capable of exposing mice and rats to a wide range of inhaled agents for extended periods of time. A major component of the research supported by the parent grant of this supplement, the Vermont Lung Center NCRR-COBRE program 'Translational research in lung biology (RR 15557) involves the study of animal models of human lung disease. Many of the diseases in which we are particularly interested arise from chronic exposure to inhaled agents of various kinds. These agents include environmental allergens such as ovalbumin and house dust mite extract, and pollutants such as nitrogen dioxide, acrolein silica dust, and asbestos. Inhalational exposure protocols are essential for all research of this nature. The purpose of this supplement is therefore to construct a new inhalational exposure facility (IEF) at the University of Vermont to replace the facility currently being decommissioned. This will allow us to take our COBRE-funded research to the next level by providing a modern inhalational exposure facility that uses the most up-to-date equipment, including a nose-only exposure system, for generating mouse models of lung disease. The new facility will be housed in renovated space within the College of Medicine. A manager will be hired to oversee operation of the facility.
Project Description: Please see award descr above
Infrastructure Description: Lung diseases in general, and particularly those associated with chronic exposure to environmental agents, constitute a major and growing public health burden. A new inhalational exposure facility at the University of Vermont will have a major impact on the University's ability to continue its tradition of front-line research into the pathophysiology of environmental lung disease, and will particularly impact NCRR-funded studies. Specific to the purpose of the Recovery Act, this supplement will preserve and create jobs and promote economic recovery by the hiring of additional staff, renovation of space (preserving construction jobs) and procurement of additional equipment.
Jobs Summary: N/A (Total jobs reported: 0)
Project Status: Not Started
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