Grant: $15,900 - National Institutes of Health - Jun. 2, 2009
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Award Description: The overall research program explores the molecular mechanisms by which estrogen and estrogen receptors control vascular tone and inhibit vascular injury and atherosclerosis. The work has been developed and evolved over the past decade in a series of molecular, cellular and mouse studies in total body knockout mouse models and the studies are of central relevance to clinical questions in cardiovascular health and disease in both men and women. The summer student will join this program and the research workforce to implement SA3 of the parent grant, which focuses on creating and studying exciting new genetically modified mice that allow vascular cell-specific, inducible disruption of estrogen receptor (ER) ? or ER? on an ApoE background to explore the hypothesis in the setting of atherosclerosis. These unique mice are now fully available in our laboratory and an enormous opportunity now exists to accelerate the study of SA3 and the central hypothesis that VSMC ER mediates estrogen inhibition of VSMC proliferation during vascular injury and atherosclerosis.
Project Description: Significant progress was made on SA3 by addition of the summer student.
Infrastructure Description: N/A
Jobs Summary: Assist in vascular injury, staining sections, immunohistochemistry, and data analysis. Conduct cell culture studies with vascular cells to explore how cell-specific ER expression in vascular cells alters VSMC and/or EC cellular biology. (Total jobs reported: 1)
Project Status: More than 50% Completed
This award's data was last updated on Jun. 2, 2009. Help expand these official descriptions using the wiki below.