Rector & Visitors of The University of Virginia
Grant: $71,102 - National Institutes of Health - Sep. 22, 2009
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Award Description: We propose an Administrative Supplement, under the Recovery Act (NOT-OD-09-056), to parent grant, NIH R37 HD025594, 'Cell Motility and Cell Interactions During Neurulation'. The work proposed here will greatly accelerate and extend the progress, and enhance the significance of work on the second and third parent grant aims, which are to determine the role of the planar cell polarity (PCP) pathway (2nd aim), and the role of small GTPases (3rd aim) in controlling the polarized cell motility underlying cell intercalation that drive convergent extension (CE) tissue movements of the neural plate and underlying mesoderm, which together generate the forces that shape and close the neural tube. This supplement will accelerate the progress of our research because it provides the key element we need, skilled, informed technical help. We have the methods in place under the parent grant, and we are proceeding with the parent grant goals, but the discovery of the myosin II involvement in the newly described node/cable cytoskeleton, and force production points to the supplemental experiments described here as ones greatly enhancing the goals of the parent grant, and indeed essential to interpret the parent grant experiments at a deeper level, and ones greatly accelerating our understanding. It provides for the hiring of two laboratory specialists, one full time and one 7/12 time, for two years, specialists who will both be in need of employment at or near the anticipated start date.
Project Description: See Award Description;
Jobs Summary: None (Total jobs reported: 0)
Project Status: Not Started
This award's data was last updated on Sep. 22, 2009. Help expand these official descriptions using the wiki below.
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