Grant: $358,812 - National Institutes of Health - Sep. 3, 2009
0% voted satisfied - 100% voted not satisfied - 1 vote(s) cast
Award Description: Excessive exposure to manganese results in basal ganglia pathology and enhanced production of inflammatory mediators (cytokines, nitric oxide, prostaglandins) by activated glia in vitro. At present, there are no in vivo studies describing the nature of the interaction between manganese and an inflammagen nor are there studies describing the regional specificity and extent of the neuropathology associated with such an interaction. We hypothesize that exposure to manganese will potentiate inflammation in mice challenged peripherally with an inflammagen in a brain region-specific manner, resulting in persistent neuroinflammation and selective neuronal loss in the basal ganglia. We also hypothesize that both astrocytes and microglia will contribute to the neu-roinflammation, with microglia playing a dominant role earlier in the process. The project has the following Specific Aims: 1) determine, in a time-, brain region (striatum, globus pallidus, thalamus, substantia nigra)-, concentration-, and route of exposure-dependent fashion, the molecular alterations caused by peripheral man-ganese exposure alone or in combination with an inflammagen challenge; 2) determine the role that Egr1 plays in the manganese-inflammagen induced neuroinflammation. The proposed investigations will aid in delineating the molecular mechanisms of the interaction between manganese and inflammagens in the induction of neurodegeneration and the role of microglia vs. astrocytes in the process.
Project Description: Project not started, funded on 9/5/09.
Jobs Summary: Not started (Total jobs reported: 0)
Project Status: Not Started
This award's data was last updated on Sep. 3, 2009. Help expand these official descriptions using the wiki below.