Grant: $67,938 - National Institutes of Health - Sep. 18, 2009
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Award Description: The synaptonemal complex (SC) is a proteinaceous scaffold that juxtaposes homologous chromosomes (homologs) during the pachytene stage of meiosis. Crossovers/chiasmata form in the context of the SC mediating homolog segregation to opposite spindle poles. In humans, CS defects are associated with chromosome imbalances, birth defects and sterility. Functions of the SC remain unknown. Since initiation of the parent grant, two subaims hae been accomplished: (i)Non-random placement of crossovers along meiotic chromosomes was found to be linked with structural modifications of the SC via the widely conserved ATPase Pch2( joshi et al., 2009, Plos Genet., in press). (ii) To identify functions of fully assembled SC, efficient desctruction via inducible proteolysis was demonstrated for SC central element component Xip1. For the administratve supplement, a genome-wide screen for proteins that when overexpressed substitute for Zip1 functins in homolog segregation will be prioritized. Identification of zip1 multicopy supressors will help (i) defining functions of the SC central element and 9ii) identifying novel gene functions in meiotic chromosome segregation. The supplement will provide employment to a graduate student and part-time faculty and increase the tempo of scientific discovery relevant to reproductive health.
Project Description: See award description.
Jobs Summary: None. (Total jobs reported: 0)
Project Status: Not Started
This award's data was last updated on Sep. 18, 2009. Help expand these official descriptions using the wiki below.