Fred Hutchinson Cancer Research Center
Grant: $33,596 - National Institutes of Health - Aug. 14, 2009
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Award Description: My research project focuses on the role of CyclophilinA (CypA) in retroviral restriction. CypA is a Peptidyl-Prolyl Isomerase and has a complex relationship with lentiviruses. In human cells, CypA increases HIV infectivity, while in Old World Monkey cells CypA decreases infectivity in the presence of TRIM5á. I am currently investigating CypA in the form of TRIMCyp, a fusion gene made up of the CypA and TRIM5 genes. TRIMCyp fusion genes have previously been identified in two phylogenetically and geographically distinct primats and are known to have anti-retroviral activity.
Project Description: 'Initiated studies on TRIMCyp project. '
Jobs Summary: Fellowship for Raymond V Malfavon-Borja (Total jobs reported: 0)
Project Status: Less Than 50% Completed
This award's data was last updated on Aug. 14, 2009. Help expand these official descriptions using the wiki below.
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