Grant: $109,847 - National Institutes of Health - Jul. 17, 2009
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Award Description: This administrative supplement will allow us to accelerate the tempo of our research by hiring assitional staff. The long-term objectives of this project are to investigate the mechanisms regulating neural regeneration and to develop strategies to enhance recovery and restore function following injury. The development of our mild and severe olfactory injury models will enable us to evaluate the effectiveness of chemical agents directed at improving recovery outcome. Our preliminary findings using an anti-inflammatory agent (dexamethasone) have proven effective in reducing the amount of scar formation and increasing neuronal recovery. With the hiring of additional personnel we will increase the number of experiments we can perform and our ability to test novel agents for their effectiveness. We will continue to investigate the role of matrix metalloproteinases (MMPs) in injury and repair processes and use specific MMP inhibitor molecules to modulate MMP levels at critical time points after injury in an attempt to optimize long term recovery. The hiring of additional staff wil lallow us to process more tissue samples, cut and stain more sistological sections, and increase our capacity to process and analyze data. The acceleration of the pace of our research could lead to a more rapid development of therapeutic interventions directed ar improving recovery of olfactory function following injury.
Project Description: Progress is being made towards all aspects of the project as described in the Award Description field
Jobs Summary: 1 Laboratory Specialist, 1 Graduate Student Research Assistant (Total jobs reported: 2)
Project Status: Less Than 50% Completed
This award's data was last updated on Jul. 17, 2009. Help expand these official descriptions using the wiki below.