Grant: $73,615 - National Institutes of Health - Sep. 18, 2009
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Award Description: This supplement will allow us to apply some new techniques to develop transgenic mice that have single copy integrations of a highly expanded trinucleotide repeat.
Project Description: This project will use ES cell technology and cell-free cloning to develop a transgenic mouse model of myotonic dystrophy type 1. The expected outcome is a mouse model for conditional expression of the myotonic dystrophy gene. The model will express a transgene mRNA having a highly-expanded, non-coding, uninterrupted CUG repeat. This model will be particularly suited for studies of repeat instability in somatic cells, and for preclinical steps of therapeutic development.
Jobs Summary: This award has just been issued no jobs have been created or retained as of this date. (Total jobs reported: 0)
Project Status: Not Started
This award's data was last updated on Sep. 18, 2009. Help expand these official descriptions using the wiki below.