MISSOURI SYSTEM, UNIVERSITY OF
Grant: $27,000 - National Institutes of Health - Sep. 22, 2009
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Award Description: This project combines 1) in vivo, retrospective assessment of the severity of any post-radiation dental lesions as related to factors such as radiation field parameters, the radiation dose to which teeth were exposed, and the use of salivary gland radiation protector drugs; 2) in vitro chemical, mechanical, and morphologic analyses of structure and properties of in vivo irradiated teeth as compared to non-irradiated teeth; 3) the structure/property relationships will be used in finite element modeling of the stress distribution within irradiated teeth under simulated functional loading conditions; 4) developing the infrastructure and acquiring the preliminary data to continue the investigation as a prospective, longitudinal clinical trial for future grant applications in order to correlate the initiation and progression of post-radiation dental lesions to additional clinical factors such as xerostomia and occlusal patterns, as well as radiation dose, field parameters, and the use radiation protector drugs.
Project Description: This project combines 1) in vivo, retrospective assessment of the severity of any post-radiation dental lesions as related to factors such as radiation field parameters, the radiation dose to which teeth were exposed, and the use of salivary gland radiation protector drugs; 2) in vitro chemical, mechanical, and morphologic analyses of structure and properties of in vivo irradiated teeth as compared to non-irradiated teeth; 3) the structure/property relationships will be used in finite element modeling of the stress distribution within irradiated teeth under simulated functional loading conditions; 4) developing the infrastructure and acquiring the preliminary data to continue the investigation as a prospective, longitudinal clinical trial for future grant applications in order to correlate the initiation and progression of post-radiation dental lesions to additional clinical factors such as xerostomia and occlusal patterns, as well as radiation dose, field parameters, and the use radiation protector drugs.
Jobs Summary: Award setup in PeopleSoft on 10/2/2009; no salaries entered to date. (Total jobs reported: 0)
Project Status: Less Than 50% Completed
This award's data was last updated on Sep. 22, 2009. Help expand these official descriptions using the wiki below.
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