Grant: $304,254 - National Institutes of Health - May. 21, 2009
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Award Description: The degradation of proteins within cells controls multiple cellular processes. Protein degradation is used to control the division of cells, and defects in degrading cell cycle regulatory proteins can lead to cancer. Many cellular proteins are degraded by cullin-RING ubiquitin ligases (CRLs). There are many different CRL complexes, and the mutation of several CRL components is causally linked to cancer and other human diseases. All CRL complexes are inhibited by the protein CAND1, which binds directly to the core CRL complex. Currently it is not known how CAND1 binding to CRLs, or its release from CRLs, is controlled. This project uses genetic approaches to discover how CAND1-mediated inhibition of CRLs is regulated. Understanding how CRL activity is controlled is the foundation for developing therapeutics to treat diseases that are caused by aberrant CRL activity.
Project Description: As defined in the Award Description field.
Infrastructure Description: N/A
Jobs Summary: Prime Recipient retained one Postdoctoral Researcher and one Graduate Research Assistant; and created positions for two Research Technicians and one Temporary Worker. (Total jobs reported: 2)
Project Status: Less Than 50% Completed
This award's data was last updated on May. 21, 2009. Help expand these official descriptions using the wiki below.