Grant: $313,915 - National Institutes of Health - Sep. 30, 2009
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Award Description: Ready access to seven-membered rings systems will facilitate the synthesis of biologically important compounds possessing this ring system. Three carbocyclic cores of three targets, thapsigargin, grayanotoxin III and guanacastepene J, will be synthesized to demonstrate the synthetic utility, efficiency, and flexibility of the allenic cyclocarbonylation reaction. Realization of the goals of this proposal will provide a more general understanding of allenes and transition-metal catalyzed cyclocarbonylation reactions. Moreover, the long-term goals of this project are the application of this strategy to the total synthesis of thapsigargin, guanacastepene J and grayanotoxin III that will feature access to novel intermediates and analogs enabling new biological studies.
Project Description: Research on this award is in the beginning. We were just informed about the award on 9/30/09. The award start date is 9/30/09. We are now in the process of organizing the research activities.
Infrastructure Description: N/A
Jobs Summary: AWARD START DATE IS SEPTEMBER 30, 2009 â¿¿ no one has been appointed to this award yet. (Total jobs reported: 0)
Project Status: Not Started
This award's data was last updated on Sep. 30, 2009. Help expand these official descriptions using the wiki below.