UNIVERSITY OF FLORIDA
Grant: $214,932 - National Institutes of Health - Jul. 16, 2009
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Award Description: Cocaine abuse continues to be an important public-health concem. Because cocaine abuse is not an automatic consequence of cocaine use, it is important to study factors that may lead from the latter to the former. Two such factors that have been implicated in cocaine abuse (and in the abuse of other drugs, as well) are tolerance and sensitization that can develop as a result of repeated exposure to the drug. Overwhelming evidence now indicates that behavioral factors can playa role in whether, and the degree to which, tolerance or sensitization occurs. This application is to request continued support for research on behavioral factors involved in the development of tolerance and sensitization to behavioral effects of cocaine. Specifically, the research will have two major aims. The first is to expand the analysis of the way in which ostensibly subtle differences in how consequences of behavior occur modulate the development of tolerance and/or sensitization to effects of cocaine on that behavior. The second is to examine a potential behavioral mechanism, sensitivity to startle, of cocaine's effects on a model of purposive behavior that reveals tolerance to the drug's effects.
Project Description: Two of the proposed 7 studies are underway. We expect these to be completed no later than January. We have ordered and received animals for two additional studies that will begin before the end of October.The PI was employed for part of the summer term. 2 graduate assistants have been employed since the beginning of the Fall academic term. A laboratory-technician position has been established, and the position should be filled by the end of September.
Jobs Summary: Job1: Laboratory Technician who will oversee daily operation of the lab. Jobs 2 and 3: Partime effort by graduate-student research assistants. Job 4: Employment of the PI during summer months. (Total jobs reported: 2)
Project Status: Less Than 50% Completed
This award's data was last updated on Jul. 16, 2009. Help expand these official descriptions using the wiki below.
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